Transactions 2006 Through Monday, June 19th
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| Team Name | Replaced | Picked Up |
| Priory of Yawkey Way | Released - Fernando Rodney | Roger Clemens |
| Rooster Rage | DL - Jay Gibbons | Shawn Green |
| Make 7up Yours | DL - Tyler Walker | Ted Lilly |
| Camel Jockeys | Released - Sean Marshall | Joe Blanton |
| A.C.L. | Released - Jason Lane | Jason Kubel |
| Asian Pranksters | DL - Eric Gagne | Taylor Tankersley |
| Iron Men | DL - Josh Willingham | Marcus Thames |
| Priory of Yawkey Way | Released - Jeromy Burnitz | Lastings Milledge |
| A.C.L. | Released - Casey Janssen | Elizardo Ramirez |
| Iron Men | DL - Frank Thomas | Jose Castillo |
| Priory of Yawkey Way | Released - Clay Hensley | Activated - Bartolo Colon |
| Camel Jockeys | Reserved - Horacio Ramirez | Chien-Ming Wang |
| Non - Smokers | Released - Milton Bradley | No Open Spot |
| Non - Smokers | Reserved - Jason Isringhausen | Gil Meche |
| Sultans of Swat | Released - Logan Kensing | Activated - Zach Duke |
| Sultans of Swat | Released - David Weathers | No Open Spot |
| Asian Pranksters | Released - Willy Tavares | Luis Gonzalez |
| Winged Buffalo | Reserved - Jarrod Washburn | Scott Olsen |
| The Bigg Doggs | Reserved - Dave Roberts | Phil Nevin |
| Iron Men | Minors - Jered Weaver | Activated - Mark Prior |
| Sultans of Swat | Reserved - Michael Cuddyer | Activated - Jorge Cantu |
| Non - Smokers | DL - Cliff Floyd | No Open Spot |
| Non - Smokers | DL - Casey Blake | No Open Spot |
| A.C.L. | Released - Wilson Betemit | Activated - Joe Crede |
| A.C.L. | Reserved - Tony Armas Jr. | Activated - Esteban Loaiza |
| Harpooners | Released - Michael Barrett | No Open Spot |
| Harpooners | Released - Moises Alou | No Open Spot |
| Sultans of Swat | Released - Jose Guillen | No Open Spot |