Transactions 2006 Through Monday, September 11th
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| Team Name | Replaced | Picked Up |
| A.C.L. | Released - Javy Lopez | Activated - Josh Bard |
| A.C.L. | Taxi - Travis Hafner | Activated - Casey Blake |
| The Bigg Doggs | Taxi - Jeremy Hermida | Activated - Shawn Green |
| The Bigg Doggs | Taxi - Morgan Ensberg | Activated - Coco Crisp |
| The Bigg Doggs | Released - Jorge Julio | Activated - Francisco Liriano |
| Priory of Yawkey Way | Released - Justin Duchscherer | Activated - Randy Wolf |
| Harpooners | Taxi - Mark Teahen | Activated - Ty Wigginton |
| Rooster Rage | DL - Yorvit Torrealba | Brian Schneider |
| Rooster Rage | Taxi - Ken Griffey Jr. | Activated - Emil Brown |
| Iron Men | Taxi - Tony Pena | Activated - Chad Billingsley |
| Iron Men | Released - Livan Hernandez | Activated - Huston Street |
| A.C.L. | Released - Esteban Loaiza | Activated - Kyle Davies |
| Winged Buffalo | Taxi - Adrian Beltre | Activated - Mike Sweeney |
| Non - Smokers | Released - Freddy Garcia | Activated - Tom Gordon |
| Non - Smokers | Taxi - David Delucci | Activated - Luke Scott |
| Camel Jockeys | Released - Jose Castillo | Activated - Khalil Greene |
| Camel Jockeys | Taxi - Roger Clemens | Activated - Joe Blanton |
| Sultans of Swat | Reserved - Carlos Zambrano | Activated - Pedro Martinez |
| Sultans of Swat | Taxi - Jason Isringhausen | Activated - Scot Shields |