Transactions 2006 Through Monday, May 1st
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| Team Name | Replaced | Picked Up |
| Sultans of Swat | Released - Dave Roberts | Corey Patterson |
| Camel Jockeys | DL - Rich Harden | Tony Armas Jr. |
| The Bigg Doggs | Released - Mike Maroth | Akinori Otsuka |
| Priory of Yawkey Way | Released - Ryan Langerhans | Juan Encarnacion |
| Rooster Rage | Released - Mark Kotsay | Bill Hall |
| A.C.L. | DL - John Patterson | Wandy Rodriguez |
| Non - Smokers | Released - Vicente Padilla | Activated - Trevor Hoffman |
| Harpooners | Released - Adam LaRoche | Ben Broussard |
| Harpooners | Released - Ty Wiggington | Activated - Chipper Jones |
| Iron Men | Released - Ryan Church | Frank Thomas |
| Make 7up Yours | DL - Brian Roberts | Jose Lopez |
| Make 7up Yours | Reserved - Francisco Cordero | Jason Johnson |
| Sultans of Swat | Reserved - Fernando Rodney | Activated - Todd Jones |
| Non - Smokers | Reserved - Milton Bradley | Ryan Zimmerman |
| Non - Smokers | Reserved - Yadier Molina | Miguel Olivo |
| Winged Buffalo | Released - Jason Michaels | Activated - Carlos Beltran |
| Winged Buffalo | Reserved - Jeff Mathis | Brian Schneider |
| A.C.L. | Reserved - Adrian Beltre | Joe Crede |
| A.C.L. | Released - Jeff Weaver | Sean Marshall |
| Rooster Rage | Released - Dan Miceli | Orlando Hernandez |
| Rooster Rage | Released - Mike Cameron | No Open Spot |
| Priory of Yawkey Way | Released - Ryan Madson | Cory Lidle |
| Iron Men | Released - Justin Duchscherer | Activated - Huston Street |
| Iron Men | Reserved - Shawn Chacon | Jeff Suppan |
| Iron Men | Reserved - Kelvim Escobar | Sidney Ponson |
| Camel Jockeys | Released - Oliver Perez | Activated - Jeremy Bonderman |
| Sultans of Swat | DL - Jorge Cantu | Todd Walker |
| Sultans of Swat | Released - Jack Wilson | Activated - Shawn Green |
| Harpooners | Released - J.J. Putz | Activated - Armando Benitez |
| A.C.L. | DL - Esteban Loaiza | No Open Spot |