Transactions 2006 Through Monday, May 8th
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| Team Name | Replaced | Picked Up |
| Camel Jockeys | Released - Tony Armas Jr. | J.J. Putz |
| Iron Men | Released - Sidney Ponson | Juan Cruz |
| Non - Smokers | Released - Ryan Zimmerman | Ty Wiggington |
| The Bigg Doggs | Released - Jake Westbrook | Gustavo Chacin |
| Asian Pranksters | Released - Aaron Boone | Activated - Todd Helton |
| A.C.L. | DL - Javy Lopez | David Ross |
| Rooster Rage | Released - Orlando Hernandez | Ted Lilly |
| Make 7up Yours | Released - Jason Johnson | Joel Pineiro |
| Make 7up Yours | Released - Francisco Cordero | No Open Spot |
| Iron Men | Released - Jeff Suppan | Nate Robertson |
| Non - Smokers | Released - Yadier Molina | No Open Spot |
| The Bigg Doggs | Released - Joey Gathright | Dave Roberts |
| Rooster Rage | Reserved - Gary Sheffield | Wily Mo Pena |
| Non - Smokers | Reserved - Joe Blanton | Vicente Padilla |
| Non - Smokers | Reserved - Jason Isringhausen | Jeff Francis |
| Non - Smokers | DL - Milton Bradley | No Open Spot |
| The Bigg Doggs | Reserved - Matt Cain | Activated - Noah Lowry |
| Winged Buffalo | Reserved - Juan Uribe | David Eckstein |
| Winged Buffalo | Minors - Jeff Mathis | No Open Spot |
| Winged Buffalo | Reserved - Odalis Perez | Woody Williams |
| Priory of Yawkey Way | DL - Mike Sweeney | Brandon Inge |
| Priory of Yawkey Way | Released - J.J. Hardy | Activated - Julio Lugo |
| Sultans of Swat | DL - Mike Lieberthal | Sal Fasano |
| Sultans of Swat | Released - Fernando Rodney | No Open Spot |
| Iron Men | Released - Shawn Chacon | Activated - Kelvim Escobar |
| Iron Men | Released - Brandon McCarthy | No Open Spot |
| A.C.L. | Released - Adrian Beltre | No Open Spot |