Transactions 2006 Through Monday, May 22nd
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Trades: Asian Pranksters traded Todd Helton, Justin Verlander, and the St. Louis Organization to the Camel Jockeys for Brad Lidge, Lyle Overbay, and the Arizona Organization.
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| Team Name | Replaced | Picked Up |
| Rooster Rage | Released - Ambiorix Burgos | Matt Cain |
| Camel Jockeys | Released - Chad Qualls | Sean Marshall |
| Iron Men | Released - Dan Wheeler | Todd Coffey |
| Asian Pranksters | Released - Keith Foulke | Livan Hernandez |
| Make 7up Yours | Released - Bubba Crosby | Activated - Brian Roberts |
| Sultans of Swat | Released - Luis Castillo | Dan Uggla |
| Rooster Rage | Released - Chan Ho Park | Nate Robertson |
| Asian Pranksters | Released - Jason LaRue | Russell Martin |
| Sultans of Swat | Released - Sal Fasano | Mike Matheny |
| Rooster Rage | Released - Adrian Beltre | Omar Vizquel |
| Rooster Rage | Reserved - Eddie Guardado | Vicente Padilla |
| The Bigg Doggs | Reserved - Chris Reitsma | Joe Blanton |
| Sultans of Swat | Reserved - Jose Guillen | Michael Cuddyer |
| Winged Buffalo | Reserved - Joe Borowski | Chien-Ming Wang |
| Winged Buffalo | Released - Jeff Suppan | Activated - Brad Penny |
| Non - Smokers | Reserved - Ryan Freel | Freddy Sanchez |