Transactions 2006 Through Monday, April 3rd
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| Team Name | Replaced | Picked Up |
| Iron Men | DL - Mark Prior | Dan Miceli |
| The Bigg Doggs | Released - Chad Orvella | Tim Worrell |
| Asian Pranksters | DL - Jason LaRue | Javier Valentin |
| Winged Buffalo | DL - Mike MacDougal | Jarrod Washburn |
| Sultans of Swat | DL - Todd Jones | Fernando Rodney |
| Harpooners | DL - Armando Benitez | Danny Graves |
| Camel Jockeys | DL - Ben Sheets | Kyle Davies |
| Rooster Rage | DL - Mike Cameron | Mark Kotsay |
| Priory of Yawkey Way | DL - Adam Eaton | Ryan Madson |
| The Bigg Doggs | DL - A.J. Burnett | Jake Westbrook |
| Winged Buffalo | DL - Rocco Baldelli | Luis Gonzalez |
| Sultans of Swat | DL - Kerry Wood | Jae Seo |
| Sultans of Swat | Reserved - Mike Lowell | Casey Kotchman |
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Draft Day Trades: Sultans of Swat traded their 1st and 2nd round picks to the Rooster Rage for their 1st and 2nd round picks. Non - Smokers traded their 2nd and 3rd round picks to the Priory of Yawkey Way for their 2nd and 4th round picks. Rooster Rage traded Jorge Cantu to the Sultans of Swat for Marcus Giles. Iron Men traded Jeremy Bonderman to the Camel Jockeys for their 8th round pick. Sultans of Swat traded Ivan Rodriguez to the Winged Buffalo for their 11th round pick. Priory of Yawkey Way traded BJ Ryan and their 16th round pick to the Sultans of Swat for Julio Lugo and their 14th round pick. |
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