Transactions 2008 Through Monday, April 7th
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| Team Name | Replaced | Picked Up |
| Winged Buffalo | Released - Rafael Betancourt | Jon Rauch |
| Non - Smokers | Released - Luis Castillo | Jeff Keppinger |
| Springfield Isotopes | Released - Joey Votto | Nick Johnson |
| Priory of Yawkey Way | Released - Tom Glavine | Randy Wolf |
| Winged Buffalo | Released - John Buck | Ryan Doumit |
| Non - Smokers | Released - Dave Roberts | Scott Hairston |
| Springfield Isotopes | Released - Tom Gordon | Activated - Brad Lidge |
| Priory of Yawkey Way | Released - Mike Mussina | Activated - Andy Pettitte |
| Winged Buffalo | DL - Michael Cuddyer | Xavier Nady |
| Non - Smokers | DL - J.J. Putz | Wandy Rodriguez |
| Camel Jockeys | DL - Chad Cordero | Ervin Santana |
| Camel Jockeys | DL - Dioner Navarro | Jason Kendall |
| What Would Elijah Dukes Do ? | Released - Paul LoDuca | Yadier Molina |
| A.C.L. | Released - Erick Aybar | Jose Lopez |
| Reserve Moves | ||
| Winged Buffalo | Reserved - Kevin Slowey | Jake Westbrook |
| A.C.L. | Reserved - Chris Duncan | Carlos Quentin |
| Reversal of Fortune | Reserved - Adam LaRoche | Ryan Church |