Transactions 2008 Through Monday, April 14th
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| Team Name | Replaced | Picked Up |
| I Like Big Bunts | DL - Ty Wigginton | Mike Jacobs |
| Springfield Isotopes | DL - Shane Victorino | Jason Kubel |
| Non - Smokers | DL - Dontrelle Willis | Edwin Jackson |
| The Bigg Doggs | Released - Tony Pena | Peter Moylan |
| A.C.L. | DL - Rich Harden | Jonathan Sanchez |
| I Like Big Bunts | Released - Bronson Arroyo | Kason Gabbard |
| Springfield Isotopes | Released - Nick Johnson | Jason Werth |
| Non - Smokers | DL - Mike Lowell | Joey Gathright |
| Winged Buffalo | Released - Jon Rauch | Activated - Randy Johnson |
| Winged Buffalo | DL - Kevin Slowey | No Open Spot |
| A.C.L. | DL - Matt Garza | Dana Eveland |
| A.C.L. | DL - Rafael Soriano | Rafael Betancourt |
| A.C.L. | Released - Jose Lopez | Erick Aybar |
| A.C.L. | Released - Austin Kearns | Activated - Chris Duncan |
| What Would Elijah Dukes Do ? | Released - Heath Bell | Joe Saunders |
| Reversal of Fortune | Released - Adam LaRoche | No Open Spot |
| BALCO Bombers | Released - Jeff Francis | Livan Hernandez |
| Reserve Moves | ||
| Priory of Yawkey Way | Reserved - Barry Zito | Scott Baker |
| Non - Smokers | Reserved - Aaron Rowand | Rajai Davis |
| Non - Smokers | Reserved - Todd Jones | Todd Wellemeyer |
| Winged Buffalo | Reserved - Jeremy Accardo | Activated - B.J. Ryan |
| Winged Buffalo | Reserved - Jack Cust | Joe Crede |
| Reversal of Fortune | Reserved - Tom Gorzelanny | Mark Lowe |