Transactions 2008 Through Monday, September 8th
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| Team Name | Replaced | Picked Up |
| The Bigg Doggs | Released - J.J. Putz | Activated - Joba Chamberlain |
| The Bigg Doggs | Released - Jensen Lewis | Activated - Jonathan Sanchez |
| The Bigg Doggs | DL - Jeff Kent | Marco Scutaro |
| I Like Big Bunts | Released - Melvin Mora | Activated - Mike Lowell |
| I Like Big Bunts | Minors - Clay Buchholz | Activated - Jon Garland |
| Priory of Yawkey Way | Released - Mike Aviles | No Open Spot |
| Camel Jockeys | DL - Howie Kendrick | Jeff Keppinger |
| Reversal of Fortune | Released - Orlando Hudson | No Open Spot |
| Reversal of Fortune | Released - Glen Perkins | No Open Spot |
| Iron Men | Released - Pedro Martinez | Activated - Max Scherzer |
| Reserve Moves | ||
| A.C.L. | Taxi - Dan Wheeler | Activated - Josh Beckett |
| What Would Elijah Dukes Do ? | Taxi - Ty Wigginton | Activated - Edgar Renteria |
| The Bigg Doggs | Taxi - Rick Ankiel | Activated - Michael Bourn |
| Priory of Yawkey Way | Taxi - Gary Sheffield | Activated - Hideki Matsui |
| Reversal of Fortune | Taxi - Ryan Garko | Activated - Pedro Sandoval |
| Reversal of Fortune | Taxi - Ryan Theriot | Activated - Clint Barmes |
| Reversal of Fortune | Taxi - Ricky Nolasco | Activated - Shaun Marcum |
| Winged Buffalo | Taxi - Jesus Flores | Activated - Jasson Varitek |
| Non - Smokers | Taxi - Carlos Quentin | Activated - Mark Teahen |
| Non - Smokers | Taxi - Wandy Rodriguez | Activated - Brandon Morrow |
| A.C.L. | Taxi - Armando Galarraga | Yusmeiro Petit |