Transactions 2008 Through Monday, September 15th
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| Team Name | Replaced | Picked Up |
| Priory of Yawkey Way | Released - Jorge Campillo | Activated - George Sherrill |
| Iron Men | Released - Troy Percival | No Open Spot |
| Reserve Moves | ||
| Sultans of Swat | Taxi - Adrian Beltre | Activated - Felipe Lopez |
| Reversal of Fortune | Taxi - Josh Willingham | Activated - Ryan Garko |
| Reversal of Fortune | Taxi - Matt Cain | Activated - Ricky Nolasco |
| Reversal of Fortune | Taxi - Brian Schneider | Activated - Ryan Church |
| The Bigg Doggs | Taxi - Troy Glaus | Activated - Eric Hinske |
| Priory of Yawkey Way | Taxi - Paul Konerko | Activated - Brandon Inge |