Transactions 2008 Through Monday, April 21st
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| Team Name | Replaced | Picked Up |
| Reversal of Fortune | Released - Mark Lowe | Cliff Lee |
| Priory of Yawkey Way | Released - Asdrubal Cabrera | Mark DeRosa |
| Non - Smokers | Released - Rajai Davis | Ryan Ludwick |
| Springfield Isotopes | Released - Jason Werth | Joey Votto |
| BALCO Bombers | DL - Joe Borowski | Jeff Francis |
| Winged Buffalo | DL - Jimmy Rollins | Orlando Hudson |
| The Bigg Doggs | DL - Alfonso Soriano | Melky Cabrera |
| Reversal of Fortune | Released - Tom Gorzelanny | No Open Spot |
| Non - Smokers | DL - Wandy Rodriguez | Activated - Todd Jones |
| The Bigg Doggs | DL - Peter Moylan | Gavin Floyd |
| Non - Smokers | Released - Scott Hairston | Activated - Aaron Rowand |
| Camel Jockeys | DL - Howie Kendrick | Bobby Crosby |
| Camel Jockeys | Released - Jeremy Guthrie | Activated - Francisco Liriano |
| Winged Buffalo | Released - Jack Cust | No Open Spot |
| Sultans of Swat | DL - Pedro Martinez | John Danks |
| Sultans of Swat | DL - Erik Bedard | Ryan Dempster |
| Priory of Yawkey Way | Released - Barry Zito | No Open Spot |
| Winged Buffalo | Released - Jeremy Accardo | No Open Spot |
| Reserve Moves | ||
| Winged Buffalo | Reserved - Jake Westbrook | Jon Rauch |
| Camel Jockeys | Reserved - Ben Sheets | Activated - Chad Cordero |
| Camel Jockeys | Reserved - Placido Polanco | Jose Lopez |
| Springfield Isotopes | Reserved - Jonathan Broxton | Manny Acosta |
| What Would Elijah Dukes Do ? | Reserved - Ian Kennedy | Activated - Yovani Gallardo |
| I Like Big Bunts | Reserved - Gary Sheffield | Activated - Jeremy Hermida |
| Sultans of Swat | Reserved - Felix Pie | John Bowker |
| Sultans of Swat | Reserved - Jason Bartlett | David Eckstein |
| A.C.L. | Reserved - Jeremy Bonderman | Hong-Chih Kuo |