Transactions 2008 Through Monday, March 31st
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| Team Name | Replaced | Picked Up |
| Priory of Yawkey Way | DL - Andy Pettitte | Mike Mussina |
| Non - Smokers | DL - John Lackey | Edinson Volquez |
| Camel Jockeys | DL - Scott Kazmir | Jeremy Guthrie |
| Winged Buffalo | DL - Chris Carpenter | Greg Maddux |
| Springfield Isotopes | DL - Brad Lidge | Tom Gordon |
| Priory of Yawkey Way | DL - Eric Chavez | Mark Reynolds |
| Non - Smokers | DL - Curtis Granderson | Dave Roberts |
| Camel Jockeys | Minors - Francisco Liriano | Jair Jurrjens |
| Winged Buffalo | DL - B.J. Ryan | Rafael Betancourt |
| Non - Smokers | DL - Kaz Matsui | Luis Castillo |
| Camel Jockeys | DL - Mark Prior | Scott Olsen |
| Winged Buffalo | DL - Randy Johnson | Kevin Slowey |
| I Like Big Bunts | DL - Jeremy Hermida | Andre Ethier |
| What Would Elijah Dukes Do ? | DL - Yovani Gollardo | Heath Bell |
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Draft Day Trades: The Sultans of Swat traded Edgar Renteria to the Priory of Yawkey Way for Dan Uggla.
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