Transactions 2010 Through Monday, August 30th
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| Team Name | Replaced | Picked Up |
| The Bigg Doggs | Released - Randy Wolf | Mike Pelfrey |
| WWEDD? | Released - Jonathan Broxton | Bobby Jenks |
| The Bigg Doggs | Released - Omar Infante | Activated - Ryan Theriot |
| A.C.L. | Released - Brandon Lyon | Activated - Francisco Liriano |
| A.C.L. | Released - Kelly Shoppach | Activated - Geovany Soto |
| A.C.L. | Released - Yunel Escobar | No Open Spot |
| Priory of Yawkey Way | Released - Cody Ross | Ryan Raburn |
| Non - Smokers | Released - Jose Guillen | Activated - Scott Podsednik |
| Non - Smokers | Released - Bud Norris | Activated - Kevin Gregg |
| Camel Jockeys | Released - Ricky Nolasco | No Open Spot |
| Sultans of Swat | Released - John Lackey | No Open Spot |
| Priory of Yawkey Way | Released - A.J. Burnett | Activated - Wade Davis |
| Reserve Moves | ||
| The Bigg Doggs | Reserved - Franklin Gutierrez | Activated - Nelson Cruz |
| BALCO Bombers | Reserved - Brett Cecil | Activated - Jhoulys Chacin |
| BALCO Bombers | Reserved - Jonny Gomes | Activated - Nyjer Morgan |
| Reversal of Fortune | Reserved - Jose Reyes | Jhonny Peralta |
| Winged Buffalo | Reserved - Fausto Carmona | Fernando Rodney |
| A.C.L | Reserved - Ian Stewart | Activated - Chase Utley |
| A.C.L. | Reserved - Dallas Braden | Trevor Hoffman |
| Sultans of Swat | Reserved - Matt LaPorta | Roger Bernadina |
| Winged Buffalo | Reserved - Russell Branyan | Activated - Manny Ramirez |