Transactions 2010 Through Monday, September 13th
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| Team Name | Replaced | Picked Up |
| Iron Men | DL - Jason Kendall | Chris Iannetta |
| Reversal of Fortune | Released - Alfredo Simon | No Open Spot |
| Sultans of Swat | Released - Tyler Clippard | No Open Spot |
| Sultans of Swat | Released - Troy Glaus | No Open Spot |
| BALCO Bombers | Released - Alcides Escobar | Activated - Rafael Furcal |
| BALCO Bombers | Released - Jeff Francouer | No Open Spot |
| BALCO Bombers | Released - Jack Cust | No Open Spot |
| I Like Big Bunts | Released - John Ely | No Open Spot |
| Reserve Moves | ||
| The Bigg Doggs | Taxi - Justin Upton | Activated - Franklin Gutierrez |
| The Bigg Doggs | Taxi - Joel Hanrahan | Activated - Aroldis Chapman |
| The Bigg Doggs | Taxi - Mike Pelfrey | Activated - Derek Holland |
| A.C.L. | Taxi - Johan Santana | Activated - Brandon Lyon |
| A.C.L. | Taxi - Dallas Braden | Activated - Ryan Madson |
| A.C.L. | Taxi - Matt Kemp | Activated - Corey Patterson |
| Priory of Yawkey Way | Taxi - Scott Baker | Activated - J.A. Happ |
| Priory of Yawkey Way | Taxi - Blake DeWitt | Activated - Brandon Inge |
| Winged Buffalo | Taxi - Josh Johnson | Activated - Cliff Lee |
| Winged Buffalo | Taxi - Jason Hammel | Hisanori Takahashi |
| Reversal of Fortune | Taxi - Michael Cuddyer | Activated - Marco Scutaro |
| Reversal of Fortune | Taxi - Brian Fuentes | Activated - Randy Wolf |
| Reversal of Fortune | Taxi - Nolan Reimold | No Open Spot |
| Camel Jockeys | Taxi - Josh Hamilton | Activated - Darnell McDonald |
| Camel Jockeys | Taxi - Jay Bruce | Activated - Julio Borbon |
| Sultans of Swat | Taxi - Kevin Kouzmanoff | Activated - Bill Hall |
| Sultans of Swat | Taxi - Nick Swisher | Activated - Coco Crisp |
| Sultans of Swat | Taxi - Daniel Bard | Activated - Kevin Slowey |
| BALCO Bombers | Taxi - J.P. Arencibia | No Open Spot |
| BALCO Bombers | Taxi - Scott Sizemore | No Open Spot |