Transactions 2010 Through Monday, April 19th
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Trades: Camel Jockeys traded Daisuke Matsusaka, Justin Masterson, and Chris Iannetta to I Like Big Bunts for Matt Cain and Nick Hundley.
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| Team Name | Replaced | Picked Up |
| Reversal of Fortune | DL - Brian Fuentes | Fernando Rodney |
| Non - Smokers | Released - Brandon Morrow | Kevin Gregg |
| Priory of Yawkey Way | Released - Conor Jackson | Jose Guillen |
| Iron Men | Released - Jason Hammel | Jaime Garcia |
| WWEDD? | Released - Frank Francisco | Brad Penny |
| Sultans of Swat | Released - Dontrelle Willis | Dallas Braden |
| Winged Buffalo | DL - Kelly Shoppach | Miguel Olivo |
| Camel Jockeys | Released - Luke Hochevar | Colby Lewis |
| I Like Big Bunts | DL - Mike Gonzalez | Daniel Bard |
| I Like Big Bunts | Released - Nick Swisher | Activated - Julio Borbon |
| Sultans of Swat | Released - Jeremy Bonderman | Kevin Millwood |
| WWEDD? | DL - Jimmy Rollins | Alex Gonzalez |
| Priory of Yawkey Way | Released - Carlos Gomez | No Open Spot |
| Non - Smokers | Released - Dexter Fowler | Scott Podsednik |
| Reversal of Fortune | Released - Daric Barton | Rick Ankiel |
| Non - Smokers | Released - Tim Wakefield | Mike Pelfrey |
| Sultans of Swat | Released - Pat Burrell | Juan Rivera |
| Sultans of Swat | Released - Mark Ellis | Alberto Callaspo |
| Winged Buffalo | Released - Mat Latos | Activated - Fausto Carmona |
| A.C.L. | Released - Ian Kennedy | Activated - Shaun Marcum |
| A.C.L. | Released - Ian Desmond | Activated - Alexei Ramirez |
| Iron Men | Released - Chris Perez | No Open Spot |
| Iron Men | Released - Jake Fox | Activated - Lance Berkman |
| Iron Men | Released - Chris B. Young (AZ) | Activated - Cameron Maybin |
| Sultans of Swat | Released - Kevin Kouzmanoff | Activated - Chipper Jones |
| Reserve Moves | ||
| Sultans of Swat | Reserved - Nate McLouth | Brett Gardner |
| The Bigg Doggs | Reserved - Aaron Harang | Randy Wells |
| The Bigg Doggs | Reserved - J.A. Happ | Joel Pineiro |
| Reversal of Fortune | Reserved - Mark DeRosa | Chase Headley |
| Camel Jockeys | Reserved - Jacoby Ellsbury | Lastings Milledge |
| Iron Men | Reserved - Clint Barmes | Eugenio Velez |
| Iron Men | Reserved - Max Scherzer | Brett Myers |